Surface-Epitope Masking (SEM)
AbstractAn immunological subtraction approach, surface-epitope masking (SEM), is described that permits the efficient and selective production of monoclonal antibodies (MAbs) reacting with both known...
View ArticleComplete Open Reading Frame (C-ORF) Technique
AbstractSeveral approaches, generally referred to as rapid amplification of cDNA ends, are currently used as a means of obtaining full-length cDNA clones by PCR. However, these protocols are not...
View ArticleCloning Differentially Expressed Genes Using Rapid Subtraction Hybridization...
AbstractDifferential gene expression represents the entry point for comprehending complex biological processes. In this context, identification and cloning of differentially expressed genes represent...
View ArticleCurrent advances in ER stress intervention therapies
AbstractThe endoplasmic reticulum (ER) is the site of synthesis and folding of membrane-localised and secretory proteins. The load upon ER client proteins that cells process varies considerably...
View ArticleSH3GL2 is frequently deleted in non-small cell lung cancer and downregulates...
AbstractThe purpose of this study was to identify key genetic pathways involved in non-small cell lung cancer (NSCLC) and understand their role in tumor progression. We performed a genome wide scanning...
View ArticleExpression patterns of MDA-9/syntenin during development of the mouse embryo
AbstractMelanoma differentiation associated gene-9 (MDA-9)/syntenin is a PDZ domain-containing adaptor protein involved in multiple diverse cellular processes including organization of protein...
View ArticleThe role of tumor-associated macrophages in tumor vascularization
AbstractTumor vascularization is a highly complex process that involves the interaction between tumors and their surrounding stroma, as well as many distinct angiogenesis-regulating factors. Tumor...
View ArticleHIV induces expression of complement component C3 in astrocytes by...
AbstractBackgroundAbnormal activation of the complement system contributes to some central nervous system diseases but the role of complement in HIV-associated neurocognitive disorder (HAND) is...
View ArticleMDA-9/Syntenin/SDCBP: new insights into a unique multifunctional scaffold...
AbstractTumor metastasis comprises a series of coordinated events that culminate in dissemination of cancer cells to distant sites within the body representing the greatest challenge impeding effective...
View ArticleTumor-specific imaging through progression elevated gene-3 promoter-driven...
Bhang and colleagues have developed a tumor-specific imaging strategy that uses the progression elevated gene-3 (PEG-3) promoter, known to be specifically associated with malignant transformation, to...
View ArticleNovel ZnO hollow-nanocarriers containing paclitaxel targeting...
AbstractLow pH in the tumor micromilieu is a recognized pathological feature of cancer. This attribute of cancerous cells has been targeted herein for the controlled release of chemotherapeutics at the...
View ArticleUpregulation of neuronal astrocyte elevated gene-1 protects nigral...
AbstractThe role of astrocyte elevated gene-1 (AEG-1) in nigral dopaminergic (DA) neurons has not been studied. Here we report that the expression of AEG-1 was significantly lower in DA neurons in the...
View ArticleMulti-nucleated cells use ROS to induce breast cancer chemo-resistance in...
AbstractAlthough there is a strong correlation between multinucleated cells (MNCs) and cancer chemo-resistance in variety of cancers, our understanding of how multinucleated cells modulate the tumor...
View ArticleRegulation of neuroblastoma migration, invasion, and in vivo metastasis by...
AbstractDespite multi-modality treatments, prognosis for advanced stage neuroblastoma (NB) remains challenging with residual long-term disabilities in survivors. Advanced stage NB is metastatic, which...
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